Pharma-Nutrition

Dr. G. Folkerts started his career in the Rudolf Magnus Institute for Pharmacology at the Utrecht University. He did his thesis on viral infections and asthma and is appointed as full professor (Chair COPD and In Vivo Pharmacology) in the division of Pharmacology, Department of Pharmacy, Faculty of Sciences. He spent some time at the University of Edmonton (Canada), the Wellcome Research Institute in Beckenham (UK) and Janssen Research Foundation in Beerse (Belgium). He has successfully guided a great number of research projects concerning inflammatory diseases. These activities have resulted in more than 160 scientific publications in well-respected international journals. He is a full-time professor at the Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands. He is also an associated editor of The European Journal of Pharmacology and is CEO of the contract research company Curax BV.Dr. Johan Garssen studied medicine and biology at the Free University, Amsterdam, the Netherlands. He specialized in immunology and pharmacology. He completed his PhD thesis at the University of Utrecht on the role of T cells in respiratory allergy, an immunopharmacological approach. This PhD program was partly performed at Yale University, New Haven, USA. After a postdoc period, he became senior scientist at the National Institute of Public Health in the Netherlands. There he coached many research projects, both preclinical as well as clinical research, in the field of immunomodulation induced by a.o. nutritional ingredients, drugs and environmental agents. He became head of the immunology section at Numico-Research, Wageningen, the Netherlands and director of the immunology platform of Nutricia Research (formerly Numico and Danone), medical nutrition and infant nutrition. He now is a full professor in immunopharmacology at the Utrecht Institute for Pharmaceutical Sciences, Utrecht University and has been nominated University Profiling Professor Immunopharmacology. Additionally, he has published more than 370 peer reviewed papers in the field of immunomodulation.

• 1 Introductory Chapter.- 2 New Developments in Food Safety Assessment: Innovations in Food Allergy and Toxicological Safety Assessment.- 3 Bridging a Pharma-Like Innovation Gap in Medical Nutrition.- 4 Modulation of the Gut Ecosystem in Irritable Bowel Syndrome.- 5 The Role of Omega-6 and Omega-3 Fatty Acids in Inflammatory Bowel Disease.- 6 N-3 Polyunsaturated Fatty Acid and Neuroinflammation in Aging: Role in Cognition.- 7 Nutritional Programming of Immune Defense Against Infections in Early Life?.- 8 Impact on Non-Digestible Oligosaccharides on Gut Associated Lymphoid Tissue and Oral Tolerance Induction.- 9 The Endocannabinoid System: Molecular Connection between Nutrition and Pharmacology.- 10 Effects of Natural products on Pharmacokinetics and Pharmacodynamics of Drugs.- 11 Nutrition and Gastrointestinal Health as Modulators of Parkinson’s Disease.- 12 Eat to Heal: Natural Inducers of the Hem Oxygenase-1 System.- 13 Recent Developments in the Treatment of Cachexia.- 14 Individualized Tumor Therapy: Biomarkers and Possibilities for Targeted Therapy with Natural Products.- 15 Nutrition in Oncology: from Treating Cachexia to Targeting the Tumor.- 16 Nutraceuticals in Preventive Oncology: Chemical Biology and Translational Pharmaceutical Science.- 17 The Onset Of Eczema: Underlying Mechanisms.- 18 Cow’s Milk Allergy: Protein Hydrolysates or Amino Acid Formula.- 19 Allergen Avoidance Versus Tolerance Induction.- 20 Nutrition and Cognitive Decline in Older Persons: Bridging the Gap between Epidemiology and Intervention Studies.- 21 Nutraceutical Regulation of the Neuroimmunoendocrine Super System.- 22 Targeting (Gut)-Immune-Brain Axis with Pharmaceutical and Nutritional Concepts: Relevance for Mental and Neurological Disorders.- 23 Nutritional Approaches for Healthy Aging of the Brain and the Prevention of Neurodegenerative Disease.