A Guide to Particulate Science in Pharmaceutical Product Development

The pharmaceutical applications of powder technology have long been recognized. Yet while many books focus on aspects of powder formation and behaviour, there are few texts that explore the power of particulate science in the design, manufacture, and control of quality medicines. This revision discusses key principles and practical applications. The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behaviour of particles and powder, instrumental analysis, particle size measurement and synergy of adopted techniques, and in vitro and in vivo performance criteria. Case studies are included in this new edition. This fully revised edition provides an essential account of particulate science including a new chapter on multicomponent particles as well as product case studies. Presents a variety of topics ranging from the quality of published data on particle size in pharmaceuticals, to the future of crystal engineering. Reviews methods of particle measurement and their importance for specific applications. Discusses misconceptions and misunderstandings of particulate science together with lessons from other industries. Outstanding and highly respected authors in their field provide a new edition with an impressive breadth of coverage.