Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy, Third Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

The fully updated and expanded third edition covers the basic biology of adenoviruses, highlights the potential use adenoviral vectors for the treatment of disease including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for vet applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine application and virotherapy, and oncolytic adenoviruses for anti-tumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

• Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
• Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
• Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
• Discusses utility of adenoviral vectors in animal disease models
• Considers Federal Drug Administration regulations for human clinical trials