Advances in Pharmacokinetics and Pharmacodynamics

This book provides a concise overview of recent advances inPharmacokinetics (PK) and Pharmacodynamics (PD).The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as wellas the assessment of food effect on drug absorption using PBPK modeling(Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models andtheir applications to pharmacokinetic data.The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice andstudies. Chapter 6 deals with the subject/physiology variability issueencountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.