Alzheimer's Disease: Risk Factors, Pathogenesis, Biomarkers and Potential Treatment Strategies

Alzheimer's disease (AD) refers to a progressive brain disease, which gradually destroys thinking skills and memory, as well as the capacity to perform even basic tasks. It is one of the leading causes of progressive dementia. There are several factors that contribute to the development of AD, but the most significant risk factor is aging. Intracellular neurofibrillary tangles and extracellular aggregates of amyloid β (Aβ) plaques made up of hyperphosphorylated τ-protein in limbic and cortical parts of the human brain have been linked to its pathogenesis. The biomarkers of AD are neurochemical indicators, which are utilized to determine the presence or risk of the disease. One of the well-recognized biomarkers of AD is amyloid beta (Aβ), which can be utilized to diagnose AD at an early stage in addition to tracking the progression of the disease. There is currently no cure for this disease and existing treatments provide only minor symptomatic relief, and are therefore considered palliative. This book contains some path-breaking studies related to Alzheimer's disease. It attempts to examine the risk factors, pathogenesis, biomarkers and potential treatment strategies related to Alzheimer's disease. Those in search of information to further their knowledge will be greatly assisted by this book.