Artificial Cellulosome

Clostridium thermocellum achieves efficient cellulose degradation using multiprotein extracellular enzymatic complexes, termed cellulosomes. In this study an artificial cellulosome based on the modular structure of the Clostridium-cellulosome was developed which exhibits at least the degradation level of the native cellulosome. In this systme, hydrolytic cellulases from a C. thermocellum mutant are bound to the surface of nanoparticles. Thus, a highly active renewable system could be developed, that is able to compete with the commercially available cellulase preparations.