Aspartic Proteinases and Their Inhibitors

Frontmatter -- Preface -- Acknowledgements -- Organizing Committee -- Contents -- Introduction -- Aspartic proteinases and their inhibitors / Kay, John -- Comments on the nomenclature of aspartic proteinases / Foltmann, Bent -- General aspartic proteinases -- Isolation, molecufer characteristics, and primary structures. Fungal aspartyl proteinases / Stepanov, Valentin M. -- Structure and properties of proteinase a from Saccharomyces carlsbergensis and Saccharomyces cerevisiae / Dreyer, Thomas / Halkjasr, Barbara / Svendsen, lb / Ottesen, Martin -- Pepstatin-sensitive proteinase from Chlamydomonas reinhardtii cells / Wilusz, T. / Polanowski, A. / Jones, R.F. / Jones, Raymond F. -- Purification and characterization of aspartic proteinases from Cucumis sativus and Cucurbita maxima seeds / Polanowski, Antoni / Wilusz, Tadeusz / Kolaczkowska, Maria K. / Wieczorek, Maciej / Wilimowska-Pelc, Anna / Kuczek, Marian -- Isolation and molecular characteristics of avian pepsins / Kostka, Vladimír / Pichová, Iva / BaudyS, Miroslav -- Pepsins of yak and camel. Isolation and characterization / TomáSek, Vladimír / Pohl, Jan / Kostka, Vladimír / Can-Erdene, Tudevin / Parevsuren, Badra / Dorzhpalam, Banzaryn -- Molecular variants of human aspartic proteinases / Samloff, I. Michael / Taggart, R. Thomas / Hengels, Klaus J. -- Human pepsins 1 and 2 ("fast pepsins"): Heterogeneity and carbohydrate content / Ryle, Andrew P. / Foltmann, Bent -- The primary structure of cathepsin D and the implications for its biological functions / Shewale, Jaiprakash G. / Takahashi, Takayuki / Tang, Jordan -- Some unexpected properties of cathepsin D / Wiederanders, Bernd / Kirschke, Heidrun / Schaper, Susanne / Valler, Martin J. / Kay, John -- New characteristics of a high molecular weight aspartic proteinase from bovine brain / Azaryan, Anahit / Barkhudaryan, Nina / Galoyan, Armen / Wiederanders, Bernd -- Isolation and properties of an aspartic proteinase from pig intestinal mucosa / Antonov, V.K. / Zilberman, M.I. / Vorotyntseva, T.I. -- Three-dimensional structures, hydrolytic mechanism and specificity -- X-ray diffraction analysis of porcine pepsin structure / Andreeva, N. / Zdanov, A. / Gustchina, A. / Fedorov, A. -- The high resolution structure of endothiapepsin / Blundell, Tom / Jenkins, John / Pearl, Laurence / Sewell, Trevor / Pedersen, Vibeke -- X-ray diffraction studies on penicillopepsin and its complexes: the hydrolytic mechanism / James, Michael N.G. / Sielecki, Anita R. / Hofmann, Theo -- Structure of the active site of pepsin and its complexes with inhibitors / Gustchina, Alla / Andreeva, Natalia -- The determination of the three-dimensional structure of chymosin / Safro, Mark / Andreeva, Nataliya / Zdanov, Alexander -- The extended binding cleft of aspartic proteinases and its role in peptide hydrolysis / Pearl, Laurence -- Zymogens of aspartic proteinases. Structure predictions from amino acid sequences -- Chemical approaches to the mechanism of aspartic proteinases / Antonov, Vladimir K. -- Interaction of aspartic proteinases with a new series of synthetic substrates and with inhibitors based on the propart of porcine pepsinogen / Dunn, Ben M. / Parten, Benne / Jimenez, Melba / Rolph, Carole E. / Valler, Martin / Kay, John -- Kinetic and fluorescence studies on chicken pepsin. The use of Cys 115 as the active site probe / Pohl, Jan / strop, Petr / Pichová, Iva / Bláha, Ivo / Kostka, Vladimír -- Zymogen activation pathways -- Multiplicity and intermediates of the activation mechanism of zymogens of gastric aspartic proteinases / Takahashi, Kenji / Kageyama, Takashi -- Cathepsins d and e: molecular characteristics and mechanism of activation / Turk, Vito / Lah, Tamara / Puizdar, Vida / Babnik, Joza / Kotnik, Matjaz / Kregar, Igor / Pain, Roger H. -- Activation of chicken pepsinogen and chicken pepsin propart peptide (p1 -p42) complex / Pichová, Iva / Pohl, Jan / strop, Petr / Kostka, Vladimír -- Chicken pepsin - activation peptide (p1