Bile Acids and Their Receptors

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target.Itcoversallmajor areas ofresearchin this field, from genetics, chemistry, in silico modeling,molecular biology to clinical applications,offering a cross-country viewofthe functional role of bile acids assignaling molecules, virtually acting onall major areas of metabolism. While FXR and GPBAR1are essential bileacid sensors that integrate thede novo bile acid synthesis withintestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common humanalignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.