Bone Regulators and Osteoporosis Therapy

This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and localmediators including growth factors, prostaglandins, cytokines and chemokines.Topics thathavecommandedparticular attention recently arecalcium,FGF-23,nervous system boneinteractions. Drugs that cause bone lossprovide important information on mechanism as well as therapeutic considerations.An overviewof the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.