Cell Cycle Regulation

Focuses on recent key discoveries made relating to the cell cycle and its regulation - a critical new horizon in therapeutics. Research into all aspects of cell cycle regulation has undergone explosive growth during the past decade due to the powerful techniques of molecular biology. An overall view of the cellular processes, both at the enzymatic and genetic level, has been identified in continually finer detail, as described inside this text. This has enabled significant progress in the identification of drugs capable of acting on specific components of the cell cycle, with the result that we may soon have the ability to manipulate the cell cycle pharmacologically. The potential impact on clinical conditions such as cancer, hematopoiesis, angiogenesis, inflammation, organ remodelling and apoptosis is vast. Originating from presentations at the Eighth SmithKline Beecham Pharmaceuticals United States Research Symposium, each chapter in this volume is written by an opinion leader in the field.