Chemical Genomics

Chemical Genomics: Reviews and Protocols covers all of the important roles chemical genomics plays in the challenges of extracting the maximum human benefit from genome sequencing projects. The first section presents a series of reviews that describe this important field in detail setting the stage for the protocols chapters that follow. The protocols begin with a classical example of chemical genomics in the design of small molecules as affinity ligands for specific protein families. This theme is continued with detailed protocols for in silico to protein-small molecule interactions. The remaining protocols are directed towards the aim of producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of molecules. Covering the key elements of the subject, these methods will be of genuine use to a wide variety of scientists in this rapidly expanding field.