Cholecystokinin

Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology and pathophysiological roles of cholecystokinin (CCK) peptides. It begins with a historical overview before providing in-depth chapters into the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, and the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function. Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

Cholecystokinin: From Gallbladder to Cognition and Beyond acts as a fundamental reference on all biological and clinical aspects of CCK. This volume is ideal for researchers interested in gaining in-depth knowledge about the physiological roles of CCK and its impact across health and disease.

• Provides detailed overviews of the biology, including phylogenesis, biogenesis and distribution of expression, of cholecystokinin peptides and receptors
• Explores the physiology of CCK, its metabolic functions and role in a range of medical conditions, including obesity, type 2 diabetes, tumors, nociception and cerebral disease
• Considers the latest developments in CCK-based therapeutic approaches and future directions for CCK research