Clearance of Dying Cells in a Healthy and Diseased Immune Systems

The mode of death and the clearance of dying cells has a tremendous impact on immune tolerance and alters the clearance of dying cells, which may lead to autoimmunity and persistent inflammation. Inflammatory and "dangerous" modes of death influence the process of clearance and have a crucial role in cancer and interaction with organisms that may mimic molecules appearing dying cells. These observation lead to the need of an exchange emphasizing the mammalian immune system in the context of diseases, such as inflammatory and autoimmune diseases, cancer, and infections. This volume explores a number of topics in this area including mechanisms of tolerance induction by dying cells; mechanisms of danger induction by dying cells; infection and clearance of dying cells; autoimmunity, inflammation and clearance of dying cells; clearance of dying cells in cancer; and clearance of dying cells in the pathogenesis of additional diseases. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please click here. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas. org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.