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Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a pivotal regulator of the immune response implicated in the pathogenesis of various acute and chronic inflammatory diseases. In 1993, D-dopachrome tautomerase (D-DT) was discovered during an investigation of melanogenesis. The tertiary structure of D-DT is remarkably similar to MIF, identifying D-DT as the only known eukaryotic MIF homologue discovered to date. Despite D-DT's intriguing similarities to the very well studied MIF, there have been very few reports on the biological functions and mechanisms of action of D-DT. This dissertation aimed at the functional characterization of D-DT in biological and pathophysiologic conditions.
- Format: Pocket/Paperback
- ISBN: 9783838131610
- Språk: Engelska
- Antal sidor: 100
- Utgivningsdatum: 2012-02-23
- Förlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG