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Expression of p53, Cyclin-D1 & EGFR in oral squamous cell carcinoma
Gupta Seema • Khan Huma • Kushwaha Vandana Singh
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Uppskattad leveranstid 7-11 arbetsdagar
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Oral cancer pathogenesis is a complex process involving genetic alteration during multistep carcinogenesis, growth regulation, apoptosis, immortalization, angiogenesis, invasion and metastasis. Molecular markers such as p53, Cyclin-D1 and EGFR regulate cell cycle and play important role in tumor progression and development. The present study evaluates the expressions of these molecular markers & its prognostic significance with treatment response in oral cancer patients undergoing chemoradiation. The strong positive expressions of p53, Cyclin-D1 and EGFR showed significantly lower survival as compared to negative or moderate positive expressions. Hence, expression of p53, Cyclin-D1 and EGFR may serve as a prognostic marker in oral cancer patients.
- Format: Pocket/Paperback
- ISBN: 9783659672910
- Språk: Engelska
- Antal sidor: 64
- Utgivningsdatum: 2015-01-13
- Förlag: LAP Lambert Academic Publishing