bokomslag Formulation and Development of Bilayer Floating Tablets of Nifedipine
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Formulation and Development of Bilayer Floating Tablets of Nifedipine

Dinesh Kumar Sharma Amulyaratna Behera Gurudutta Pattnaik

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  • 108 sidor
  • 2021
The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
  • Författare: Dinesh Kumar Sharma, Amulyaratna Behera, Gurudutta Pattnaik
  • Format: Pocket/Paperback
  • ISBN: 9786203410877
  • Språk: Engelska
  • Antal sidor: 108
  • Utgivningsdatum: 2021-02-15
  • Förlag: LAP Lambert Academic Publishing