From Molecule to Drug Target for Asthma

This important volume describes the latest advances in all areas of interleukin-5 (IL5) research, pooling the insights of over 65 biological researchers, pharmaceutical scientists, and clinicians, representing institutions as diverse as the Mayo Clinic, the National Lung and Heart Institute, the John Curtin School of Medical Research, the Geneva Biomedical Research Institute, the Flanders' Interuniversity Institute for Biotechnology, and the University of Tokyo. Details IL5-related antiallergy drugs currently in development at Glaxo Wellcome and Schering-Plough Research Institute! Reviewing approaches toward small molecule antagonists and inhibitors, Interleukin-5 highlights the structure and function of IL5 and IL5 receptors explores the interaction between IL5 and eotaxin analyzes agents that down-regulate IL5 production evaluates studies on IL5 knockout and transgenic mice outlines the regulation of IL5 gene expression discusses the protein structure of IL5 covers the signalling pathways used by the IL5 receptor relates the structure and role of receptor subunits in signal transduction and more! Featuring over 1250 references, tables, drawings, photographs, and micrographs, Interleukin-5 is suitable for pulmonologists and pulmonary disease specialists; immunologists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and medical school students in these disciplines.