Vetenskap & teknik
Generation and Interpretation of Morphogen Gradients
James Briscoe • Jean-Paul Vincent • Peter Lawrence
Inbunden
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Uppskattad leveranstid 5-10 arbetsdagar
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Signalling by morphogens such as the Hedgehog family, Notch, Wingless/Wnt and various growth factors is essential during embryogenesis. The establishment of concentration gradients of these morphogens plays a key role during developmental patterning in all multicellular organisms, assuring that distinct cell/tissue types and organs appear at the right place in the right time during embryogenesis. Regulation of morphogen synthesis, trafficking and diffusion are all known to play a part in setting up these gradients, and a complex web of signaling mechanisms ensures that specific responses occur at the correct threshold concentration in the recipient cells whose fate depends on these morphogens.
- Format: Inbunden
- ISBN: 9780879698812
- Språk: Engelska
- Antal sidor: 900
- Utgivningsdatum: 2010-03-22
- Förlag: Cold Spring Harbor Laboratory Press,U.S.