Genes, Behavior, and the Social Environment

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a timeoften, through a single discipline or by a narrow range of practitionerscan only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.Table of Contents Front Matter Summary 1 Introduction 2 The Impact of Social and Cultural Environment on Health 3 Genetics and Health 4 Genetic, Environmental, and Personality Determinants of Health Risk Behaviors 5 Sex/Gender, Race/Ethnicity, and Health 6 Embedded Relationships Among Social, Behavioral, and Genetic Factors 7 Animal Models 8 Study Design and Analysis for Assessment of Interactions 9 Infrastructure 10 Ethical, Legal, and Social Implications 11 Conclusion Appendix A Methodology: Data Collection and Analysis Appendix B Recommendation from the National Academy of Sciences Report, Facilitating Interdisciplinary Research Appendix C Social Environmental and Genetic Influences on Obesity and Obesity-Promoting Behaviors Appendix D The Interaction of Social, Behavioral, and Genetic Factors in Sickle-Cell Disease Appendix E Modern Epidemiologic Approaches to Interaction: Applications to the Study of Genetic Interactions Appendix F Acronyms Appendix G Biographical Sketches Index