Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research. Table of Contents Front Matter Introduction 1 Regulatory and Ethical Considerations 2 Protocol-Development Strategies 3 General Animal-Care Concerns 4 Survival Studies 5 Prolonged Nonsurvival Studies 6 Studies of Neural Injury and Disease 7 Perinatal Studies 8 Agents and Treatments 9 Behavioral Studies References Appendix A: Sample Size Determination Appendix B: Estimating Animal Numbers Appendix C: Biographical Sketches of Authoring Committee Index