Handbook of Regenerative Medicine

This book comprehensively reviews the cell-free and cell-based therapies, focusing on the therapeutic potential of extracellular vesicles (EVs) and mesenchymal stem cell-derived exosomes across various fields of regenerative medicine and disease treatment. The initial chapters present foundational insights into the application of EVs in dentistry, cardiovascular health, and kidney injury. Each chapter discusses the role of mesenchymal stem cell exosomes in targeted therapies for conditions like neurodegenerative disorders, ophthalmological diseases, and diabetes complications, examining their application of EVs and cell-free techniques in personalized medical strategies. The subsequent chapters discuss the advanced diagnostic and therapeutic applications, including the use of EVs as biomarkers in liquid biopsies, as well as novel tissue engineering and cell-free scaffolding techniques for organ rejuvenation and tissue regeneration. Additionally, the book examines the challenges and progress in transitioning these therapies from laboratory research to clinical applications, covering critical aspects of formulation, GMP production, regulatory approval, and market access. With insights into emerging technologies like 3D cell scaffolding and theranostic applications in cancer and neurodegenerative diseases, this book emphasizes the future of regenerative medicine. Key Features: 1) Provides insights into EV-based therapies and their role in regenerative medicine across multiple medical fields. 2) Discusses the potential of mesenchymal stem cell-derived exosomes in treating neurodegenerative, ophthalmological, and cardiovascular conditions. 3) Explores the cell-free scaffolding for targeted tissue and organ regeneration. 4) Reviews the current regulatory, production, and clinical challenges in bringing cell-free therapies to market. 5) Explore cutting-edge theranostic applications of EVs in oncology and neurological disorders. This book is a useful resource for researchers and students in regenerative medicine.