Insulin, chemistry, structure, and function of insulin and related hormones

Frontmatter -- ACKNOWLEDGEMENTS -- Preface -- CONTENTS -- INTRODUCTION -- SECTION I. STRUCTURE OF INSULIN -- A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals / Dodson, E.J. / Dodson, G.G. / Reynolds / Vallely, D. -- Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid / Dodson, G.G. / Cutfield, S. / Hoenjet, E. / Wollmer, A. / Brandenburg, D. -- Correlation of Structural Details of Insulin in the Crystal and in Solution / Vollmer, A. / Straßburger, W. / Hoenjet, E. / Glatter, U. / Fleischhauer, J. / Mercola, D.A. / de Graaf, R.A.G. / Dodson, E.J. / Dodson, G.G. / Smith, D.G. / Brandenburg, D. / Danho, W. -- SECTION II. PEPTIDE SYNTHESIS -- An Assessment of Protecting Group Strategies in Synthesis of Large Peptides / Meienhofer, J. -- Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase / Birr, C. / Pipkorn, R. / Gattner, H.-G. / Renner, R. / Häring, H.-U. -- [A14-Phenylalanine-Insulin]: A Synthetic Analogue / Danho, W. / Sasaki, A. / Büllesbach, E. / Gattner, H.-G. / Wollmer, A. -- [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin / Knorr, R. / Danho, W. / Büllesbach, E. / Gattner, H.-G. / Zahn, E. -- The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin / Casaretto, M. / Danho, W. / Gattner / Zahn, H. -- A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives / Gattner, H.-G. / Danho, W. -- Alternative Approach for Human Proinsulin Synthesis / Yanaihara, N. / Sakagami, M. / Yanaihara, C. -- An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments / Kung, Y-T. / Zhu, D-Y. / Qiu, X-D. / Yuan, X-W. / Ke, L-T. / Wei, W. -- SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION -- Progress Towards the Semisynthesis of Preproinsulin / Naithani, V.K. / Büllesbach, E.E. / Zahn, H. / Shield, J. / Chance, R. / Root, M.A. -- Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin / Canova-Davis, E. / Carpenter, F.H. -- Enzyme-Catalyzed Semisynthesis with Insulin Derivatives / Gattner, H.-G. / Danho, W. / Naithani, V.K. -- The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies / Friesen, H.-J. -- A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin / Drewes, S.E. / Easter, B.R.D. / Robinson, H.M. / Magojo, H.E.M. -- Preparation of Covalent Insulin Dimers / Schüttler, A. / Brandenburg, D. -- Reactions of Insulin Derivatives with ETAC Reagents / Lawton, R.G. -- SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES -- The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin / Markussen, J. / Larsen, U.D. -- Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr / Hansen, B. / Linde, S. / Sonne, 0. / Gliemann, J. -- Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1 / Bahrami, S. / Brandenburg, D. -- Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium / Tschesche, H. / Behr, W. / Wick, R. -- Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives / Uschkoreit, J. / Brandenburg, D. / Friesen, H.-J. -- Quantitative Determination of Insulin by Gradient Elution HPLC / Biemond, M.E.F. / Sipman, W.A. / Olivié, J -- Some Preliminary Findings in Isotachophoretic Analyses of Insulin / Baldesten, A. -- Studies on the Denaturation of Dissolved Insulin / Thurow, H. -- SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION -- 125 I-SpHPP-Avidin: A Tool for Hormone