Integrative Neuroscience and Personalized Medicine

Dr. Stephen H. Koslow has been an innovator and creative leader in the fields of psychopharmacology, neuroscience and informatics. He has joined efforts in all these fields by now helping to catalyze Personalized Medicine into a reality. He continues to run his own consulting company, and his efforts in Neuroinformatics, and special interest in the clinical areas of mental illness. He had worked for many years at the National Institutes of Mental Health (NIH) where he had a major leadership role in these same areas. Dr. Evian Gordon is Adjunct Associate Professor of Psychiatry at Sydney Medical School, University of Sydney. He is also the founding Director of the Brain Dynamic Centre (BDC), and heads BDC's Integrative Neuroscience Program. He is also the CEO of Brain Resource, a publicly listed biotech Company, which developed out of BDC in 2001, and is now the industry affiliate of BDC. He is a pioneer of 'intergrative neuroscience' and has over 25 years in bringing together complementaryhuman brain imaging technologies. With his experience he has established the first fully standardized international database on the human brain, under the auspices of Brain Resource. He has over 350 peer-reviewed publications and has produced a 14-part television series on models of the human brain.

• PREFACE, Herbert Pardes, MDINTRODUCTION, Stephen H. Koslow, PhD and Evian Gordon, MD, PhD GENESIS OF PERSONALIZED MEDICINE1. The History of Personalized Medicine, Edward Abrahams, Ph.D. and Michael Silver2. An Applied Context for Personalized Medicine in Psychiatry, Alan F. Schatzberg, MD3. Personalized Medicine and Integrative Neuroscience: Towards Consensus Markers for Disorders of Brain Health, Leanne Williams, PhD and Evian Gordon MD, PhDPERSONALIZED MEDICINE AND MENTAL DISORDERS4. Does fMRI have a role in personalized health care for psychiatric patients?, Alex Fornito, MD and Edward T. Bullmore, MD5. Stress and the Impact of Personalized Medicine, Charles F. Gillespie, M.D., PhD, Elisabeth B. Binder, MD, PhD, Paul E. Holtzheimer, MD, and Charles B. Nemeroff, MD, PhD6. Personalized Medicine for Schizophrenia, Jacob S. Ballon, MD, Ragy R. Girgis, MD, and Jeffrey A. Lieberman, MD7. Personalized Integrative Markers for Attention Deficit/Hyperactivity Disorder in Children and Adolescents, M. Kohn, MD, S. Clarke, MD and Leanne Williams, PhDPERSONALIZED MEDICINE AND OTHER BRAIN DISORDERS8. The Role of Neuroimaging Biomarkers in Personalised Medicine for Neuro-degenerative and Psychiatric Disorders, Ellen M. Migo, Steve C. R. Williams, William R. Crum, Matthew J. Kempton and Ulrich Ettinger9. Autonomic Nervous System Markers for Psychophysiological, Anxiety and Physical Disorders, Richard Gevirtz, Ph.D., BCIAC 10. Personalized Medicine in Sleep Health, Ronald Grunstein, MD11. Theranostics and Translation towards Personalized Medicine for Multiple Sclerosis, Ariel Miller, Tamar Paperna, Opher Caspi, Izabella Lejbkowicz, Elsebeth Staun-Ram, Nili AvidanPERSONALIZED MEDICINE AND HEALTH CARE12. Brain-Related Healthcare: New Models for Personalized Medicine, David Whitehouse, MD13. Clinical Decision Support in Employee Assistance Programs: Personalizing the Therapeutic Approach, Eugene Baker, PhD 14. Economic impacts of the Personalized Medicine Tsunami, Dan Segal and David WilliamsCONCLUSION AND RECOMMENDATIONSAccelerating the Future of Personalized Medicine, Evian Gordon, MD, PhD and Stephen H. Koslow, PhD

"The way we currently treat patients in all areas of medicine leaves much to be desired. We identify clusters of symptoms in a descriptive manner, give those clusters a label that best fits, or several labels if none fits well, and then we administer drugs that were themselves, or their predecessors, discovered by serendipity over fifty years ago... This type of current standard of care is no longer acceptable. We need to bring the neuroscience discoveries ofthe last fifty years to health care and that must be done in a personalized way, matching each patient to the best treatment that is specifically individualized for that person. Gordon & Koslow bringtogether in an exemplary and much needed bookELthe standards for the new science and evidence-based personalized medicine of the future that has been much expected and is finally taking off." -- Julio Licinio, MD, Director, John Curtin School of Medical Research, CMBE, Australian National University, Canberra, Australia"This is an excellent new book about the future of medicine, and psychiatry in particular. All those interested in the future of psychiatry should read this book." --Doody's"The contents provide a comprehensive text suitable as both a pithy introduction to and a clear summary of the 'science to solutions' continuum in this developing field of Personalized Medicine and Integrative Neuroscience. The timeliness of this book's content is propitious providing bottom line information to educate practicing clinicians, health care workers and researchers, and also a pathway for undergraduate and graduates interested in further theirunderstanding of and involvement in tailored personal solutions." -- Anticancer Research"The editors have assembled a stellar group of academia and industry neuroscience contributors from the United States, Australia, Israel, and the United Kingdom...The chapter on schizophrenia is particularly comprehensive." -- Mauricio Tohen, M.D., Dr. PH, M.B.A, San Antonio, Texas"The editors have assembled a stellar group of academia and industry neuroscience contributors from the United States, Australia, Israel, and the United Kingdom...The goal of the volume is to update the reader on the concept of personalized medicine and to support the idea that a better understanding of the genomic regulation and other biomakers of mental disorders will lead to improved diagnoses and treatments." -- Mauricio Tohen, M.D., Dr.PH., MBA, TheAmerican Journal of Psychiatry