Modeling Calcium Signaling

This book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in cell biology. The book will inspire the graduate students and researchers to collaborate with experimentalists while studying the direction needed to explore the modeling literature. Organized intofourchapters,the book introduces to fractional calculus anddevoted to understanding the receptor activation by the ligand, that isThrombin via fractional model incorporating the Caputo-Fabrizio fractional operator.Itstudiesthe calcium profile in red blood cells with the help of the advection-diffusion equation.The book further studiesthe process of buffering, aidingto theloweringof thecalcium concentration in the cytosol, which rises due to calcium influx from extracellular space and intracellular storage.Amathematical model is studied to characterize the anomalous subdiffusion of cytosolic calcium.