Molecular Neurosurgery with Targeted Toxins

Inbunden, Engelska, 2005

AvRonald G. Wiley,Ronald G. Wiley,Douglas A. Lappi

2 369 kr

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Molecular Neurosurgery with Targeted Toxins covers the basic science applications of targeted cytotoxins including suicide transport, immunolesioning and neuropeptide-toxin conjugates. Included are introductory considerations and background on the toxins followed by five chapters reviewing the use of the immunotoxin 192 IgG-saporin to lesion the cholinergic basal forebrain. The emphasis is on both how to use the various agents, as well as on practical applications where the targeted toxins have been used in experiments to provide new information not previously available by any other technique. This line of work has been highly successful, and as pointed out by the authors, has provided a valuable animal model of Alzheimer's disease.

Produktinformation

Utgivningsdatum2005-03-22
Mått155 x 235 x 25 mm
Vikt718 g
FormatInbunden
SpråkEngelska
Antal sidor312
Upplaga2005
FörlagHumana Press Inc.
ISBN9781588291998

Tillhör följande kategorier

Medicin: allmänt inom Medicin
Neurokirurgi inom Medicin

to Molecular Neurosurgery.- Ribosome-Inactivating Proteins.- Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin.- Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin.- 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System.- Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin.- Cortical Cholinergic Deafferentation Induces A? Deposition.- Chemical Dissection of Brain Glucoregulatory Circuitry.- Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin.- Saporin Conjugates and Pain.- The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness.- Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons.- B Fragment of Cholera Toxin Conjugated to Saporin.