Neurotoxicology

This second edition of Neurotoxicology is valuable for scientists in government and industry who are responsible for public health and for the safe and efficient use of chemicals. This integrated approach to neurotoxicology will aid in the understanding of the sites and mechanisms of neurotoxicity, stimulate the formulation of testable hypotheses about how chemicals affect the nervous system, and help improve the risk assessment process.This edition focuses primarily on the neurobiological basis underlying neurotoxic sites and modes of action. The contents include:*molecular biological and in vitro approaches*potential cellular and molecular sites involving neuron-glia interactions*axonal transport*ion channels*metabolic influences on neurotoxicity*role of free radical formation in neurotoxicity*interaction between chemicals and trophic factors*endocrine disruptors*apoptosis in neurotoxicity*in vivo brain imaging*advances in measuring cognitive function*advances in developing quantitative models for neurotoxicology/risk assessment