New Vaccine Development

Common diseases cost the developing world an enormous amount in terms of human life, health, and productivity, as well as lost economic potential. New and effective vaccines could not only improve the quality of life for millions of residents in developing countries, they could also contribute substantially to further economic development. Using data from the World Health Organization and other international agencies, this book analyzes disease burdens, pathogen descriptions, geographic distribution of diseases, probable vaccine target populations, alternative control measures and treatments, and future prospects for vaccine development. New Vaccine Development provides valuable insight into immunological and international health policy priorities. Table of Contents Front Matter 1. Summary 2. Priority Setting for Health-Related Investments: A Review of Methods 3. Overview of the Analytic Approach 4. Comparison of Disease Burdens 5. Predictions of Vaccine Development 6. Assessing the Likely Utilization of New Vaccines 7. Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidate Vaccines 8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development 9. Findings, Conclusions, and Recommendations Appendix A: Selection of Vaccine Candidates for Accelerated Development Appendix B: The Burden of Disease Resulting from Acute Respiratory Illness Appendix C: The Burden of Disease Resulting from Diarrhea Appendix D-1: The Prospects for Immunizing Against Dengue Virus Appendix D-2: The Prospects for Immunizing Against Escherichia coli Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b Appendix D-4: The Prospects for Immunizing Against Hepatitis A Virus Appendix D-5: The Prospects for Immunizing Against Hepatitis B Virus Appendix D-6: The Prospects for Immunizing Against Japanese Encephalitis Virus Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae Appendix D-8: The Prospects for Immunizing Against Neisseria meningitidis Appendix D-9: The Prospects for Immunizing Against Parainfluenza Viruses Appendix D-10: The Prospects for Immunizing Against Plasmodium spp. Appendix D-11: The Prospects for Immunizing Against Rabies Virus Appendix D-12: The Prospects for Immunizing Against Respiratory Syncytial Virus Appendix D-13: The Prospects for Immunizing Against Rotavirus Appendix D-14: The Prospects for Immunizing Against Salmonella typhi Appendix D-15: The Prospects for Immunizing Against Shigella spp. Appendix D-16: The Prospects for Immunizing Against Streptococcus Group A Appendix D-17: The Prospects for Immunizing Against Streptococcus pneumoniae Appendix D-18: The Prospects for Immunizing Against Vibrio cholerae Appendix D-19: The Prospects for Immunizing Against Yellow Fever Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs Appendix F: Technical Notes Appendix G: Biographical Notes on Committee Members Appendix H: Additional Sources of Advice to the Committee Appendix I: Contents of Supplement to Volume II Appendix J: Preface to Volume I Appendix K: Contents to Volume I Index