Once Can Be Enough

There has recently been considerable discussion of a replication crisis in some areas of science. In this book, the authors argue that replication is not a necessary criterion for the validation of a scientific experiment. Five episodes from physics and genetics are used to substantiate this thesis: the Meselson-Stahl experiment on DNA replication, the discoveries of the positron and the omega minus hyperon, Mendels plant experiments, and the discovery of parity nonconservation. Two cases in which once wasnt enough are also discussed, the nondiscovery of parity nonconservation and the search for magnetic monopoles. Reasons why once wasnt enough are also discussed.