Optimization Technique

The present investigation was designed with an aim to formulate Chitosan (CH) films by cross-linking with Sodium citrate (Nacit), Sodium tripolyphosphate (NaTPP) or Chondroitin sulphate (CS) that shall be capable of simulating the in vitro permeation of model polar drug, 5-Fluorouracil (5-FU) and non polar drug, Indomethacin (INDO) across rat/rabbit or human epidermis. Optimization design was employed to identify and optimize various process and formulation variables significantly (p