Organofluorine Compounds in Biology and Medicine

Inbunden, Engelska, 2015

Av V Prakash Reddy, USA) Reddy, V Prakash (Missouri University of Science and Technology, Rolla, MO, V. Prakash Reddy, V Reddy

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Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds
Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways
Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

Produktinformation

Utgivningsdatum2015-01-28
Mått152 x 229 x 0 mm
Vikt620 g
FormatInbunden
SpråkEngelska
Antal sidor330
FörlagElsevier Science
ISBN9780444537485

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik
Organisk kemi inom Naturvetenskap och teknik

Dr. Prakash Reddy is currently active in research and teaching at the Missouri University of Science and Technology. He has received his Ph.D. in organic chemistry from the Case Western Reserve University, Cleveland, Ohio, and M.Phil. from the University of Hyderabad, India. He was an Adjunct and Visiting Professor at nationally reputed universities prior to joining Missouri University of Science and Technology in 2000. He received the Golden Key National Honor Society award for teaching excellence at Case Western Reserve University, and was a NASA Faculty Fellow at Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA. He has research interests in synthetic, mechanistic, and biological organic chemistry, and has significantly contributed to the area of carbocations and electrophilic reactions, superacids, and organofluorine chemistry.

1. Introduction: General aspects of organofluorine compounds2. C-F bond strengths3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies4. Effect of fluorine on the acidity and basicity5. Effect of fluorine on the metabolic stability6. Effect of fluorine on the bioavailability7. Positron emission tomography (PET) tracers8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms9. Summary and outlook