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PEGylated Protein Drugs: Basic Science and Clinical Applications
Francesco M Veronese
Inbunden
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
- Illustratör: 26 schwarz-weiße Tabellen 53 schwarz-weiße und 5 farbige Abbildungen
- Format: Inbunden
- ISBN: 9783764386788
- Språk: Engelska
- Antal sidor: 290
- Utgivningsdatum: 2009-09-18
- Förlag: Birkhauser Verlag AG