Pharmacological Targets in Metabolic Diseases

Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities serves as an in-depth guide to potential drug development targets for therapeutic advancements. It addresses both signaling pathways and specific proteins, presenting strategies to modulate the molecular and cellular changes observed in metabolic diseases through the use of new or classical drugs. This comprehensive text begins with an overview of metabolic diseases, detailing biological changes and identifying pharmacological targets at molecular, subcellular, and cellular levels, laying the foundation for targeted therapeutic interventions. The book further delves into the pharmaceutical targeting of organs, including a dedicated chapter on the gut-brain axis.

It reviews advances in metabolic syndrome research, explores inborn errors of metabolism, and examines the pharmacological potential of natural molecules. A section is devoted to the role of the microbiota in metabolic disease therapeutics, followed by discussions on the impact of aging, nanotechnology, the environment, and diagnostic techniques. This resource is essential for researchers, physicians, nutritionists, and biologists seeking detailed information on therapeutic targets for treating metabolic conditions.

• Covers the most prevalent metabolic diseases and disorders such as metabolic syndrome, diabetes mellitus (types I and II) and dyslipidemia, among others
• Includes chapters on the microbiome and environmental pollution as they relate to metabolic diseases and conditions
• Discusses cellular structures like the endoplasmic reticulum and mitochondria as pharmacological targets