Professor Theresa Coetzer’s research focusses on proteolytic enzymes as diagnostic and drug targets in African parasitic diseases: mainly animal and human trypanosomiasis (nagana and sleeping sickness) and also trichinellosis and theileriosis. She also has expertise in producing antibodies in chickens against the whole proteases and against peptides corresponding to epitopes identified in silico. Dr. Coetzer holds a DST-NRF South African Research Chair Initiative (SARChI), as Chair in Proteolysis in Haemostasis, Health and Disease.

• 1. Overview of pathogen proteases and their endogenous macromolecular inhibitors2. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors3. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling4. Aspartic proteases and their inhibitors in Trypanosomatids5. Subtype-specific HIV-1 protease and the role of hinge and flap dynamics in drug resistance: a subtype C narrative6. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms7. Cathepsin-like proteases of protozoa8. Metallo-aminopeptidases in parasites and bacteria9. Bacterial signal peptidases10. Ecotins of bacteria and protozoa11. Oligopeptidase B popping up in many pathogens as a virulence factor12. Bacterial/Mycobacterial proteasome

Select Guide Rating

Professor Theresa Coetzer’s research focusses on proteolytic enzymes as diagnostic and drug targets in African parasitic diseases: mainly animal and human trypanosomiasis (nagana and sleeping sickness) and also trichinellosis and theileriosis. She also has expertise in producing antibodies in chickens against the whole proteases and against peptides corresponding to epitopes identified in silico. Dr. Coetzer holds a DST-NRF South African Research Chair Initiative (SARChI), as Chair in Proteolysis in Haemostasis, Health and Disease.

• 1. Overview of pathogen proteases and their endogenous macromolecular inhibitors2. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors3. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling4. Aspartic proteases and their inhibitors in Trypanosomatids5. Subtype-specific HIV-1 protease and the role of hinge and flap dynamics in drug resistance: a subtype C narrative6. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms7. Cathepsin-like proteases of protozoa8. Metallo-aminopeptidases in parasites and bacteria9. Bacterial signal peptidases10. Ecotins of bacteria and protozoa11. Oligopeptidase B popping up in many pathogens as a virulence factor12. Bacterial/Mycobacterial proteasome

Select Guide Rating

Professor Theresa Coetzer’s research focusses on proteolytic enzymes as diagnostic and drug targets in African parasitic diseases: mainly animal and human trypanosomiasis (nagana and sleeping sickness) and also trichinellosis and theileriosis. She also has expertise in producing antibodies in chickens against the whole proteases and against peptides corresponding to epitopes identified in silico. Dr. Coetzer holds a DST-NRF South African Research Chair Initiative (SARChI), as Chair in Proteolysis in Haemostasis, Health and Disease.

• 1. Overview of pathogen proteases and their endogenous macromolecular inhibitors2. DNA-linked inhibitor antibody assay (DIANA) to capture proteases in complex mixtures and identify novel small-molecule inhibitors3. Recent Advances in Applications of Proteomic Approaches and Chemical Tools for Pathogen Profiling4. Aspartic proteases and their inhibitors in Trypanosomatids5. Subtype-specific HIV-1 protease and the role of hinge and flap dynamics in drug resistance: a subtype C narrative6. Gingipains of Porphyromonas gingivalis deactivators of innate immune and inflammatory defense mechanisms7. Cathepsin-like proteases of protozoa8. Metallo-aminopeptidases in parasites and bacteria9. Bacterial signal peptidases10. Ecotins of bacteria and protozoa11. Oligopeptidase B popping up in many pathogens as a virulence factor12. Bacterial/Mycobacterial proteasome

Select Guide Rating