Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

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• Presents the latest release in the Annual Reports in Medicinal Chemistry series