Reactions of the Organic Matrix in Dentin Caries

In the course of dentin caries, both demineralization and reactions with the organic matrix take place. Matrix reactions include proteolysis and covalent modifications. From the introduction and the review on discoloration in caries, it becomes clear that there are still few reports on the effect of matrix modifications on dentin caries. In this study the investigations were aimed at filling the information gap concerning the effect of reactions of dentin matrix on caries. To this end, degradation and modification of dentin were studied in demineralized specimens in vitro. In addition, specimens placed in dentures in situ and caries lesions in extracted teeth were analysed for modifications.