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Despite aggressive efforts in dengue research, the control of dengue diseases and discovery of therapeutics against them await complete elucidation of its complex immune-pathogenesis. Virtually all mammalian cells express surface major histocompatibility complex class I (MHC Class I) molecules which are crucial for immune recognition and MHC-restricted cytolysis as part of the adaptive immune response. In contrast to many viruses that escape this host's immune responses by suppressing the MHC Class I pathway, infections by Flaviviruses, such West Nile virus, have been associated with a virus-specific increase of these antigen-presenting molecules. This study presents evidence of MHC Class I gene modulation by dengue virus, hence providing a better understanding of dengue immunopathogenesis that would consequently facilitate the discovery of antiviral therapeutics against dengue.
- Format: Pocket/Paperback
- ISBN: 9783848495238
- Språk: Engelska
- Antal sidor: 204
- Utgivningsdatum: 2012-08-02
- Förlag: LAP Lambert Academic Publishing