Djur & natur
Pocket
Risedronate Effects on Bone Metastasis of Rat Mammary Tumor Cell Lines
Kelli Boyd • Gregory Hall • Elizabeth Howerth
929:-
Uppskattad leveranstid 5-10 arbetsdagar
Fri frakt för medlemmar vid köp för minst 249:-
When compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced apoptosis, had decreased ability to bind to risedronate-treated bone, and did not produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive nature of the MTA cell line may be due to MMP-2 production (possibly allowing ongoing destruction of risedronate-treated bone), continued adhesion to risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced apoptosis.
- Format: Pocket/Paperback
- ISBN: 9783847341529
- Språk: Engelska
- Antal sidor: 128
- Utgivningsdatum: 2012-02-06
- Förlag: LAP Lambert Academic Publishing