Simvastatin and segmental bone healing

Simvastatin, a statin group of molecule widely used to reduce cholesterol content in human patients. Simvastatin is basically HMG-CoA reductase inhibitor has been demonstrated to accelerate bone healing if administered orally in mouse femur fracture model. In the present study Simvastatin was administered orally with the idea of augmenting fracture healing in considerable doses without producing any pathological changes in liver and kidney tissues in rabbit model. From the parameters used in the present experimental study it was concluded that simvastatin accelerated segmental bone healing and initiated remodeling process establishing its biological osteoinductive property may be due to the stimulation of the Bone Morphogenic Protin-2(BMP-2) gene. This can be used as augmentation of bone healing in future although extensive studies are required. The author wishes to express his sincere gratitude to Dr. Shyamal Kanti Guha for his constant support and valuable guidance to complete this work.