Solubility & Dissolution Enhancement by Solid Dispersion Technique

The science and technology associated with Pharmacy has progressed enormously over the past few decades. Significant advances in the understanding of diseases have necessitated the need to optimized drug therapy. Number of difficulties faced during formulating and developing Pharmaceutical dosage form for particular drug. Physical, chemical and Pharmacological properties affect the selection of dosage form for drug. The Oral fast dissolving tablet prepared by many techniques, direct compression is one of main method to prepare oral fast dissolving tablet. Direct compression represents the simplest and most cost effective tablet manufacturing technique. This technique can now be applied to preparation of Orodispersible tablet because of the availability of improved excipients especially superdisintegrants and sugar based excipients .Clinically, nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed by physicians for inflammatory disorders. NSAIDs exert their effect through inhibition of cyclooxygenase-II, the main form of isozyme associated with inflammation. But the simultaneous inhibition of cyclooxygenase-I and the resulting gastric and renal dysfunction