bokomslag Structure-based Drug Discovery
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Structure-based Drug Discovery

Harren Jhoti Andrew R Leach

Inbunden

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  • 250 sidor
  • 2007
Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.
  • Författare: Harren Jhoti, Andrew R Leach
  • Format: Inbunden
  • ISBN: 9781402044069
  • Språk: Engelska
  • Antal sidor: 250
  • Utgivningsdatum: 2007-01-01
  • Förlag: Springer-Verlag New York Inc.