The Pauson-Khand Reaction

The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of PausonKhand-type reactions non chiral intramolecular and intermolecular versions of PausonKhand reactions asymmetric PausonKhand reaction using chiral auxiliaries the enantioselective PausonKhand reaction PausonKhand reactions catalysed by metals other than cobalt unconventional PausonKhand reactions the PausonKhand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.