Transdermal Patch Loaded Nanoparticles Containing Antidiabetic Drugs

Biodegradable nanoparticles of insulin and Repaglinide were prepared by using biodegradable polymers and lipids. The prepared nanoparticles were evaluated by physicochemical parameters and in-vitro drug release. The optimized nanoparticle formulation of insulin and Repaglinide were loaded into Transdermal patch. These patches were subjected to release studies and preclinical evaluation parameters like bioavailability studies. Based on above studies, it was concluded that a single patch is suitable to control diabetes for more than 7 days