Translation Mechanisms and Control

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of all aspects of protein synthesis and its control. The contributors describe recent insights into the fundamental steps in translation (initiation, elongation, termination, and ribosome recycling) based on high-resolution structures of the translational machinery. The signaling pathways and targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) are discussed, as are the roles of riboswitches, processing bodies (P-bodies), stress granules, and various classes of RNAs (e.g., circular RNAs). Methods to study translation dynamics, including ribosome profiling, kinetic assays, and single-molecule and single-cell fluorescence imaging, are also covered.