University of Konstanz, West Germany, April 1418, 1975

Frontmatter -- Preface -- Contents -- List of Contributors -- Significant Steps in the Discovery and Application of Pteridines / Albert, A. -- Specific Inhibition of Dihydrofolate Biosynthesis - A New Approach to Chemotherapy / Wood, H.C.S. -- Mammalian Dihydrofolate Reductase: Porcine Liver Enzyme / Poe, M. / Bennett, C.D. / Donoghue, D. / Hirshfield, J.M. / Williams, M.N. / Hoogsteen, K. -- Kinetic Studies of Escherichia Coli Dihydropteroate Synthetase / Ferone, R. / Webb, S.R. -- Dihydropteroate Synthase: Purification by Affinity Chromatography and Mechanism of Action / Suckling, C.J. / Sweeney, J.R. / Wood, H.C.S. -- The Properties of Gamma Glutamyl Hydrolase (Conjugase) from Bovine Liver / Rowe, P.B. / Silink, M. / Reddel, R. -- The Purification of Riboflavin Synthetase by Affinity Chromatography Using 7-Oxolumazines / Wrigglesworth, R. / Ginger, C.D. / Kulick, R.J. / Wood, H.C.S. -- Interaction of Riboflavin Synthetase with Analogues of 6,7-Dimethyl-8-Ribityllumazine / Plaut, G.W.E. / Beach, R.L. -- Structure-Activity Relationship Among Pteridine Derivatives and Related Quinazolines as Inhibitors of Dihydrofolate Reductases / McCormack, John J. -- Spectral Studies of Thymidylate Synthetase / Kisliuk, R.L. / Sharma, R.K. / Leary, R.P. / Beaudette, N. -- Four Folate Metabolizing Enzymes of Mouse Embryo Fibroblasts and L-Cells as Tested During the Culture Cycle / Grzelakowska-Sztabert, B. / Chmurzyriska, W. / Landman, M. -- The Activity of the Cobalamine-dependent Methionine- Synthetase (5-Methyl-5, 6, 7, 8-Tetrahydrofolic Acid: Homocysteine Methyltransferase) in Rapidly Growing Human Cells and the Effect of Some Folic Acid Derivatives and Analogues / Sauer, H. / Wilmanns, W. -- The Role of Folate Binding Proteins in Folate Metabolism / Waxman, S. -- Transport of Folate Compounds into Mammalian and Bacterial Cells / Huennekens, F.M. / Henderson, G.B. -- Transport of Folate Compounds through the Membrane of Human Lymphoblastoid Cells / Niethammer, D. / Jackson, R.C. -- The Characterization of High Molecular Weight Complexes of Folic Acid in Mammalian Tissues / Zamierowski, M. / Wagner, C. -- The Enzymic Synthesis of Pterins in Escherichia Coli / Brown, G.M. / Yim, J. / Suzuki, Y. / Heine, M.C. / Foor, F. -- Biosynthesis of Pterins in Mammalian Systems / Fukushima, K. / Eto, I. / Mayumi, T. / Richter, W. / Goodson, S. / Shiota, T. -- The Synthesis of Pterins Catalyzed by Enzymes from Drosophila melanogaster / Brown, G.M. / Fan, C.L. -- Biosynthesis of Biopterin in the Intact Rat and in Mouse Neuroblastoma Cells / Buff, K. / Dairman, W. -- Studies on the Biosynthesis of Riboflavin / Bacher, A. / Mailänder, B. / Baur, R. / Eggers, U. / Harders, H. / Schnepple, H. -- Studies on the Mechanism of Phenylalanine Hydroxylase: Detection of an Intermediate / Kaufman, S. -- Effect of Pteridine Cofactor Structure on the Regulation of Phenylalanine Hydroxylase Activity / Ayling, J.E. / Helfand, G.D. -- Interrelationships between C-1 Metabolism and Photosynthesis in Euglena Gracilis / Cossins, E.A. / Lor, K.L. -- Folate Derivatives and Patterns of C-1 Metabolism in Neurospora Crassa, Wild Type, Ser-1 and Formate Mutants / Combepine, G. / Cossins, E.A. / Chan, P.Y. -- The Biosynthesis of Folic Acid and Pteridine Cofactor (s) and its Regulation / Iwai, K. / Kobashi, M. -- Reduced Pterins as Possible Mediators in Cellular Electron Transfer / Rembold, H. -- The Handling and Metabolism of Folates in the Rat and Man, with Especial Relationship to Disease / Blair, J.A. -- Red Blood Cell Polyglutamyl Folates in Vitamin B12 Deficiency / Perry, J. / Chanarin, I. / Lumb, M. -- Novel Urinary Metabolites of Folic Acid in the Rat / Barford, P.A. / Blair, J.A. -- "Prune"/"Killer-of-Prune": A Complementary Lethal System in Drosophila Melanogaster Affecting Pteridine Metabolism / Hackstein, J.H.P. -- Kynurenine as Trigger in Pterorhodin Synthesis in Ephestia Kuhniella Z. / Müller, K. -- Growth Stimulation by 6-Phenacylisoxanthopterin