Disorders of the Blood: Genetics, Pathophysiology and Clinical Management

Blood disorders are a group of diseases that affect some part of the blood. Several organs and tissues play a major role in supporting blood and its function. These organs and tissues are bone marrow, lymphatic system, clotting proteins, spleen, liver and kidneys. The common types of blood disorders include different types of anemia, bleeding disorders, clotting disorders and blood cancers. The symptoms of blood disorders depend on which component of the blood is affected. Some major symptoms include fatigue, fever, infections and abnormal bleeding. There are several risk factors that affect the development of blood disorders. These factors incorporate aging, autoimmune diseases, exposure to certain drugs and chemicals, and liver, kidney or thyroid disease. Treatment and clinical management of blood disorders varies according to the type of disease. Some of the blood disorders are passed-down from one generation to another. Such disorders are called genetic blood disorders. Genetic defects result in red blood cells that do not perform their normal functions. Examples of genetic blood disorders include thalassemia and sickle cell anemia. The book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the study of disorders of the blood. Its extensive content provides the readers with a detailed understanding of the genetics, pathophysiology and clinical management of these disorders.