Muscle Aging, Inclusion-Body Myositis and Myopathies

Inbunden, Engelska, 2012

Av Valerie Askanas, W. King Engel, W King Engel

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Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But “you’re just getting old” is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases.Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related InterestNeuromuscular DisordersTawil and Vennance (eds); ISBN 978-0-470-65456-9European Handbook of Neurological Management, Vol 1, 2eGilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2European Handbook of Neurological Management, Vol 2, 2eGilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

Produktinformation

Utgivningsdatum2012-02-09
Mått188 x 244 x 18 mm
Vikt748 g
FormatInbunden
SpråkEngelska
Antal sidor264
FörlagJohn Wiley and Sons Ltd
ISBN9781405196468

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List of Contributors, vii Preface, xiPart 1 Muscle Aging1 Aging of the human neuromuscular system: pathological aspects, 3W. King Engel and Valerie Askanas2 Aging of the human neuromuscular system: clinical considerations, 33W. King Engel and Valerie Askanas3 Aging of the human neuromuscular system: patient vignettes, 55W. King Engel, Shalini Mahajan, and Valerie Askanas4 Mitochondrial changes in aging with particular reference to muscle, and possible clinical consequences, 81Salvatore DiMauro, Eric Schon, and Michio Hirano5 Protein degradation in aging cells and mitochondria: relevance to the neuromuscular system, 89Jenny K. Ngo and Kelvin J. A. Davies6 Human muscle protein metabolism in relation to exercise and aging: potential therapeutic applications, 97Micah J. Drummond and Blake B. RasmussenPart 2 Sporadic Inclusion-Body Myositis7 Pathogenesis of sporadic inclusion-body myositis: role of aging and muscle-fiber degeneration, and accumulation of the same proteins as in Alzheimer and Parkinson brains, 111Valerie Askanas, W. King Engel, and Anna Nogalska8 Inflammatory and autoimmune features of inclusion-body myositis, 146Marinos C. Dalakas9 Sporadic inclusion-body myositis: clinical symptoms, physical findings, and diagnostic investigations, 159Frank L. Mastaglia10 Pathologic diagnostic criteria of sporadic inclusion-body myositis and hereditary inclusion-body myopathy muscle biopsies, 168Valerie Askanas and W. King EngelPart 3 Hereditary Inclusion-Body Myopathies11 Function and mutations of the GNE gene leading to distal myopathy with rimmed vacuoles/hereditary inclusion-body myopathy, animal models, and potential treatment, 177May Christine V. Malicdan, Satoru Noguchi, and Ichizo Nishino12 GNE myopathy (hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles): clinical features and epidemiology, 191Zohar Argov, Ichizo Nishino, and Ikuya Nonaka13 Consequences of the hereditary inclusion-body myopathy-characteristic GNE mutations on muscle proteins in vivo and in vitro, 199Aldobrando Broccolini and Massimiliano Mirabella14 Function and structure of VCP mutations leading to inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia, 206Cezary Wojcik15 Clinical spectrum of VCP myopathy, Paget disease, and frontotemporal dementia: experimental models and potential treatments, 219Virginia E. Kimonis, Eric Dec, Mallikarjun Badadani, Angele Nalbandian, Jouni Vesa, Vincent Caiozzo, Douglas Wallace, Barbara Martin, Charles Smith, and Giles D. Watts16 Drosophila and mouse models of hereditary myopathy caused by mutations in VCP/p97, 230Nisha M. Badders and J. Paul TaylorIndex, 241