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Progress in the Chemistry of Organic Natural Products 115
A Douglas Kinghorn • Heinz Falk • Simon Gibbons • Yoshinori Asakawa • Ji-Kai Liu
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This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
- Format: Inbunden
- ISBN: 9783030648527
- Språk: Engelska
- Antal sidor: 203
- Utgivningsdatum: 2021-04-03
- Förlag: Springer Nature Switzerland AG