St. Andrews, Scotland, September 2124, 1982

Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds / Huennekens, F.M. / Suresh, M.R. / Grimshaw, C.E. / Jacobsen, D.W. / Quadros, E.T. / Vitols, .S. / Henderson, G.B. -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products / Taylor, Edward C. -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins / Bailey, Steven W. / Ayling, June E. -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] / Armarego, Wilfred L.F. / Waring, Paul -- Some Simple s-Triazolopteridines / Brown, Desmond J. / Shinozuka, Kazuo -- Linear Tricyclic Analogs of Pteridines / Pendergast, William / Chan, Joseph H. -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis / Boyle, Peter / Lockhart, Ronan -- Syntheses of some Blocked 7,8-Dihydropteridines / Cameron, Bobert C. / Lyall, William J.S. / Nicholson, Sidney H. / Bobinson, David H. / Suckling, Colin J. / Wood, Hamish C.S. -- Synthesis of Chiral Reduced Pteridine Coenzymes / Doyle, Paul M. / Szakolcai, Akos / Young, Douglas W. -- Report on Discussions / Benkovic, S. J. -- Chemical Aspects (2) -- Reactivity of Pteridines / Pfleiderer, Wolfgang / Baur, Ralph / Bartke, Michael / Lut, Hermann -- Synthesis and Antitumor Activity of 10-Deazaminopterins / DeGraw, J. I. / Brown, V. H. / Tagawa, H. / Kisliuk, R. L. / Gaumont, Y. / Sirotnak, F. M. -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin / Taylor, Edward C. / Tseng, Chi-Ping / Harrington, Peter J. / Beardsley, G. Peter / Rosowsky, Andrew / Wick, Michael -- The Nor-Analogues of Folic Acid / Nair, M.G. / Rozmyslovicz, Mary K. / Kisliuk, R.L. / Gaumont, Y. / Sirotnak, F.M. -- Report on Discussions / Roth, B. -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry / Nichol, Charles A. / Viveros, O. Humberto / Duch, David S. / Abou-Donia, Martha M. / Smith, Gary K. -- Pteridines in Cancer and Other Diseases / Rokos, Katharina / Rokos, Hartmut / Frisius, Hildegard / Hüfner, Michael -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing / Dhondt, Jean-Louis / Herlin, Christophe / Bonneterre, Jacques / Vie, M. Claude / Lefebvre, Jean / Demaille, Alain -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE / Blair, J.A. / Whitburn, S.B. / Pheasant, .E. / Leeming, R.J. / Morar, C. / Al-Beir, A. -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate / Kapatos, Gregory / Kaufman, Seymour -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis / Levine, Robert A. / Lovenberg, Walter / Niederwieser, A. / Leimbacher, W. / Redweik, U. / Staudenmann, W. / Curtius, H.-Ch. -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia / Niederwieser, A. / Staudenmann, W. / Wang, M. / Curtius, H.-Ch. / Atarés, M. / Cardesa-Garcia, J. -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers / Erbe, Richard W. / Wang, Jin-Chen C. -- Report on Discussions / Cotton, R. G. H. -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase / Roberts, Gordon C.K. -- Catalytic Site of Dihydrofolate Reductase / Blakley, Raymond L. / Cocco, Lennie / Montgomery, John A. / Temple, Carroll / Roth, Barbara / Daluge, Susan / London, Robert E. -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase / Freisheim, J.H. / Susten, S. S. / Delcamp, T. J. / Rosowsky, A. / Wright, J. E. / Kempton, R. J. / Blankenship, D. T. /