The Blood Brain Barrier Ultrastructure in Human Traumatic Brain Edema

This research monograph provides new knowledge in the field of transmission electron microscopy and intramembrane morphology by means of the freeze etching technique, in the three dimensional arrangement of brain blood barrier by conventional and high resolution scanning electron microscopy, in confocal microscopy and GluR1 and N- Cadherin and CAMKII immunochytochemistry. The chapters present new pathological, pathophysiology and chemical aspects concerning how the blood brain barrier structure and substructure participate in the mechanisms of brain edema formation and resolution. All current major concepts linking submicroscopic structures and nerve cell metabolism are included. This book emphasizes the importance of electron microscopic research in neurosurgery to understand the basic pathogenetic mechanisms of human brain edema. The material covers information valuable to all persons interested in the subject clinically or experimentally, from experimental neuroscientists and graduate students to neuropathologists, neurologists and neurosurgeons