Tumors of the Cervix, Vagina, and Vulva

The publication of this edition marks the transition in diagnosis of lower genital tract lesions from a largely morphologic activity to one based upon integrated assessment using microscopy and molecular biology. Furthermore, the ability to integrate these diagnostic approaches with clinical data for patient management has been heightened. The introduction of prophylactic vaccines for preventing human papillomavirus (HPV) infections and cervical cancer precursors also thrusts pathology into a new unprecedented public health role with regard to disease monitoring, which will likely expand over time. Finally, the realisation that cervical cancer is becoming increasingly preventable carries with it both a sense of accomplishment and the recognition that this must now be translated into an achievable goal of cancer prevention in underdeveloped nations. Although the text has remained concise in order to maintain the primary function of the book as an atlas rather than a comprehensive textbook, it has been substantially updated to reflect the changes in the field since the previous edition was published in 1992. In this regard, the number of illustrations, all of which are in colourr, has almost doubled. Both the text and the photomicrographs emphasise the importance of immunohistochemistry and molecular in situ hybridisation as adjuncts to morphology in routine clinical diagnosis. A binary (low-grade and high-grade squamous intraepithelial lesion) classification for histology, analogous to TBS for cytology, replaces the four-tiered dysplasia/CIS system and the three-tiered CIN system. This Atlas will be a useful reference for pathologists, residents, and students for years to come.